Chuck

Also, you gotta wonder if this cliffhanger ending does mean Chuck might come back someday in some fashion, as Zachary Levi told us.

"I've pitched some ideas to the powers that be," Zach says, "and I think it would be really fun to do...something..

Source: http://www.eonline.com/news/watch_with_kristin/chuck_over_sob_what_did_those_final/289854