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In addition, there are a number of much less common but more serious side effects of ibuprofen, which indicate a potentially serious reaction to the drug.

The National Institutes of Health particularly warns patients against weight gain, fever, classic signs of an allergic reaction (a skin rash or hives, itching, and swelling of the face and extremities), a rapid heartbeat (tachycardia), difficulty breathing, fatigue, altered vision, and jaundice..

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